Molecular
Innovation
Natural. Safer. Sustainable.
About Us
Elevating the Standard of Crop Protection
About 5Metis
Welcome to 5Metis, Inc. 5Metis is a novel mode of action and intellectual property development company solving fungicide resistance for growers worldwide by providing scientific research in the field of agriculture. Headquartered in Research Triangle Park, North Carolina, 5Metis was founded in 2021. Since its founding, 5Metis has discovered and validated multiple novel modes of action for agricultural fungicides and is now seeking partners to bring these products through registration and into the hands of growers.
Today, 5Metis leverages its natural product screening and boron chemistry (NAB) platform to deliver novel modes of action not currently found in the agrichemical industry. As a result, 5Metis compounds break resistance to existing fungicides and can reduce application rates substantially. 5Metis is the only company with this unique intellectual property, exclusive boron chemistry library, and overall know-how to drive truly differentiated solutions.
The 5Metis business model focuses on discovery and early development and collaborates with channel partners for further development of de‐risked compounds with attractive biological profiles. 5Metis is now primarily focusing on licensing its current programs and is no longer engaging in discovery and early development for new programs.
We Aim to Grow a Better World
The purpose of 5Metis is to bring the agricultural industry solutions that are differentiated and create value for growers.
About 5Metis India Private Limited
Discovery of novel modes of action by 5Metis Inc. prompted global development and regulatory efforts, which led to the formation of 5Metis India Private Limited, a wholly owned subsidiary of 5Metis Inc. that was established in 2026. The company's current objective is to register a banana Sigatoka leaf spot complex fungicide product. Development and regulatory efforts are currently underway to support this registration.
The Need: New Modes of Action
Most fungicides available today rely on modes of action commercialized over 50 years ago. These modes of action are failing due to pathogen resistance and delisting of existing chemical products, leaving growers empty-handed. Novel modes of action are needed to allow growers to control pathogens and protect yields.
Natural Solutions
5Metis was established to combine the technology platforms of natural product screening and boron chemistry to deliver novel modes of action. Both approaches are uniquely suited to identify and deliver new modes of action.
Why Natural Products?
Historically natural products have been a rich source of new modes of action. Natural product screening directly resulted in 30% of the modes of action used in pesticides today. Another 30% share structural motifs between natural products and synthetic chemical products. Natural products are undergoing a renaissance due to improved tools to discover and produce them and to their advantages over synthetic chemicals such as greater community acceptance.
Why Boron?
Boron-containing molecules have “shape-shifting” and “speargun-like” properties that allow for unique interactions with target enzymes. 5Metis’ proprietary boron-containing library and expertise proven in the pharmaceutical industry allow its scientists to discover new modes of action to meet the needs of growers.
