Meet The Team
5Metis Team
Cody Averette, B.S.
Cody received his B.S. in Business Administration with a concentration in Management from East Carolina University. While in school he worked as a contractor for Bayer CropScience in Pikeville, NC. After graduating in 2019 he went and worked for Syngenta in RTP as a contractor. (Hover to Read More)
Cody received his B.S. in Business Administration with a concentration in Management from East Carolina University. While in school he worked as a contractor for Bayer CropScience in Pikeville, NC. After graduating in 2019 he went and worked for Syngenta in RTP as a contractor. His passion for agriculture research and growing crops comes from his time spent working on his family farm where he farmed 1,200 acres of corn and soybeans alongside his dad and brother in Renston, NC. At 5Metis, Cody is the greenhouse manager where he is responsible for management and oversight of the 5Metis greenhouse facility.
Katie Clements, M.S.
Katie received her B.S. in Biology and M.S. in Marine Science from the University of North Carolina at Wilmington. Her biology degree was focused on antibiotic discovery from bacterial isolates in the Cape Fear River. Working in the antibiotic discovery field as an undergraduate lead to her research within the Drug DISCOvery laboratories as their lead cell culturist and subsequently her MS degree in marine science with a (Hover to Read More)
Katie received her B.S. in Biology and M.S. in Marine Science from the University of North Carolina at Wilmington. Her biology degree was focused on antibiotic discovery from bacterial isolates in the Cape Fear River. Working in the antibiotic discovery field as an undergraduate lead to her research within the Drug DISCOvery laboratories as their lead cell culturist and subsequently her M.S. degree in marine science with a concentration in microbiology. During her master’s degree Katie worked with bacteria isolated from various parasitic infections of marine invertebrates within the Cape Fear. Several of these bacterial isolates were uncovered to contain antiviral, antitumor, or antibiotic properties. Publication(s) of these works are expected within the next two years. Katie joined the 5Metis team in March of 2022 as a Research Associate of the R&D team within the company. When not in the lab Katie can often be found hiking in the Blue Ridge Mountains with friends, reading, or watching a classic film.
Larry Creemer, M.S.
After receiving his B.S. in Chemistry from Michigan Technological University Larry began working as a Medicinal Chemist at Merrell Dow Pharmaceuticals in Indianapolis. He then finished his M.S. in Organic Chemistry from Purdue University and joined the Natural Products Discovery group at Eli Lilly and Company working on Spinosyn analogs for both Lilly and DowElanco. (Hover to Read More)
After receiving his B.S. in Chemistry from Michigan Technological University Larry began working as a Medicinal Chemist at Merrell Dow Pharmaceuticals in Indianapolis. He then finished his M.S. in Organic Chemistry from Purdue University and joined the Natural Products Discovery group at Eli Lilly and Company working on Spinosyn analogs for both Lilly and DowElanco. This ultimately led to the co-invention of the commercially successful naturalide insectide spinetoram. Larry finished out his time at Lilly in the chemistry discovery and early development at Elanco Animal Health. Larry the discovery chemistry effort at Dow AgroSciences (now Corteva), investigating new Active compounds, and then moved to regulatory chemistry making C14 radio tracers, metabolites and reference standards and eventually became an External Technology Manager. Since September of 2021 he has been the Senior Director of Chemistry for 5Metis, Inc., designing and executing the Medicinal Chemistry Program while directing the overall chemistry efforts of the company. In August of 2024, he became a Senior Research Fellow for 5Metis, Inc., advising and overseeing the Synthesis Programs for the company. He has 16 U.S. Patents, 18 peer reviewed publications and 5 book chapters to his credit, currently.
Rich Gianni, MBA
Rich has over 35 years of experience in Accounting and Finance, including 25 years in technology start-up companies. He is a CPA and holds a B.S. in Accounting from University of Steubenville and an MBA from Duke University Fuqua School of Business. (Hover to Read More)
Rich has over 35 years of experience in Accounting and Finance, including 25 years in technology start-up companies. He is a CPA and holds a B.S. in Accounting from University of Steubenville and an MBA from Duke University Fuqua School of Business. Prior to joining 5Metis, Rich served as the CFO of Boragen, contract CFO of Advanced Animal Diagnostics, CFO of Ziptronix Inc., CFO at nTouch Research, and VP of Finance and Administration at Celotek. At 5Metis, Rich is responsible for all aspects of Finance and Administration.
Brian Green, Ph.D.
Brian was a co-founder of 5Metis and now serves as the CEO and CSO. Previously, he was also a co-founder of AgriMetis where he was the VP of R&D. At AgriMetis, Brian was a co-inventor on key IP sold to multinational corporations, built a high performing R&D team, assisted in deal negotiations, and supported fundraising rounds totaling more than $30 million. (Hover to Read More)
Brian was a co-founder of 5Metis and now serves as the CEO and CSO. Previously, he was also a co-founder of AgriMetis where he was the VP of R&D. At AgriMetis, Brian was a co-inventor on key IP sold to multinational corporations, built a high performing R&D team, assisted in deal negotiations, and supported fundraising rounds totaling more than $30 million. Prior to AgriMetis, he worked at Acidophil, where he was involved in various aspects of company creation and management, including leading the research programs of ZuvaChem (merged with BioSyntha). Earlier in his career, he conducted postdoctoral work at Johns Hopkins University after receiving his doctorate from the University of California, San Francisco. He in an inventor on 10 US patents or PCT applications and has authored 10 peer-reviewed articles, including a first author Science publication.
Yuba Kandel, Ph.D.
Dr. Yuba Kandel received his B.S. and M.S. degrees from Tribhuvan University, Nepal then joined the Nepal Agriculture Research Council. After more than four years of plant pathology research in Nepal, he went on to receive his Ph.D. from South Dakota State University. His Ph.D. research evaluated germplasm and mapped QTLs for resistance to bacterial leaf streak of wheat. (Hover to Read More)
Dr. Yuba Kandel received his B.S. and M.S. degrees from Tribhuvan University, Nepal then joined the Nepal Agriculture Research Council. After more than four years of plant pathology research in Nepal, he went on to receive his Ph.D. from South Dakota State University. His Ph.D. research evaluated germplasm and mapped QTLs for resistance to bacterial leaf streak of wheat. Yuba joined Iowa State University as a postdoctoral research associate then research scientist in plant pathology, conducting research on plant diseases for nearly nine years. At ISU his research was focused on evaluating fungicides in field and in controlled environments as a part of developing best disease management practices for soybean and corn diseases. Yuba’s research has aided many commercial growers, crops scouts and agribusiness employees in decisions that impact yield of farming operations and economics.
Yuba has authored several peer-reviewed and extension publications and is a recipient of the 2022 Professional and Scientific Research Award from the College of Agriculture and Life Sciences at Iowa State University. At 5Metis, Yuba works as a research scientist in crop protection R&D team. Outside of work, Yuba enjoys playing ping pong and volleyball.
Shengyou Long, M.S.
Shengyou received his B.S. and M.S. in chemistry from Beijing Agricultural University in 1988 and then went on to work as an associate professor and director for pesticide process and discovery, which earned its $20M project at Hunan Research Institute of Chemical Industry (HRICI) in China. (Hover to Read More)
Shengyou received his B.S. and M.S. in chemistry from Beijing Agricultural University in 1988 and then went on to work as an associate professor and director for pesticide process and discovery, which earned its $20M project at Hunan Research Institute of Chemical Industry (HRICI) in China. In 1999, he moved to the USA where he was a visiting scholar at North Carolina State University, focused on insect hormone analog synthesis and its bioactivity study. Then after, he gained many years of experience in process chemistry and drug discovery in pharmaceutical companies. Most recently, Shengyou came back to the pesticide industry as a formulation chemist where he developed challenging and market competitive pesticide formulations at ADAMA. Shengyou joined 5Metis in December 2021 as a lead formulation chemist.
He is an inventor on several patents.
Megan Mackowiak, PMP
Megan holds her B.S. in Food Science from North Carolina State University and began her career in Food Safety & Quality Assurance. Megan then returned to NCSU to earn a Masters in Microbial Biotechnology, a degree that integrates science and MBA-level coursework with real-world industry experience. (Hover to Read More)
Megan holds her B.S. in Food Science from North Carolina State University and began her career in Food Safety & Quality Assurance. Megan then returned to NCSU to earn a Masters in Microbial Biotechnology, a degree that integrates science and MBA-level coursework with real-world industry experience. While in the program, she joined Boragen as a Safety & Compliance intern, before transitioning to a full-time Program Manager upon graduation. She joined 5Metis as a Program Manager, where she planned and organized programs across multiple market segments to align the science progression with the business objectives. She obtained her Project Management Professional (PMP)® certification, and she also studied under Timothy Pastoor, Ph,D, to specialize in Regulatory Safety. Today, Megan is 5Metis’ Regulatory Safety Program Manager, where she combines her program management capabilities with planning and executing 5Metis’ toxicity testing program. In her free time, she likes to cook, paint, and read.
Timothy Pastoor, Ph.D.
Dr. Pastoor earned his Ph.D. in toxicology from the University of Michigan, is certified by the American Board of Toxicology (DABT) and has over 40 years of experience in the field of toxicology, human health risk assessment, and regulatory affairs. (Hover to Read More)
Dr. Pastoor earned his Ph.D. in toxicology from the University of Michigan, is certified by the American Board of Toxicology (DABT) and has over 40 years of experience in the field of toxicology, human health risk assessment, and regulatory affairs. Tim is past president of the Health and Environmental Sciences Institute (HESI) where he collaborated with academic, government, industry, and NGO scientists to resolve difficult health and safety issues. Tim retired from Syngenta in 2015 and was lured out of retirement by 5Metis’ fascinating boron-based science and the fast pace of molecule discovery by the company’s highly skilled and dedicated scientists. A perfect day for Tim outside of his professional pursuits is to fly-fish and play tennis on the same day, or take a long hike with his wife, Denise.
Jason Speake, Ph.D.
Jason has a long history of success in leading discovery chemistry efforts. After obtaining his Ph.D. in chemistry at Indiana University, he spent many years in medicinal chemistry leading discovery teams at GlaxoSmithKline, Targacept, Scynexis, Avista, and Cambrex resulting in multiple clinical candidates across a variety of therapeutic areas. (Hover to Read More)
Jason has a long history of success in leading discovery chemistry efforts. After obtaining his Ph.D. in chemistry at Indiana University, he spent many years in medicinal chemistry leading discovery teams at GlaxoSmithKline, Targacept, Scynexis, Avista, and Cambrex resulting in multiple clinical candidates across a variety of therapeutic areas. In 2020, Jason transitioned to agricultural chemistry upon joining Oerth Bio to lead the discovery of targeted protein degraders for use in crop protection, before ultimately joining 5Metis in May 2024. Jason has over 50 patents, patent applications, and publications.
Murray Spruill, J.D., Ph.D.
Murray has extensive experience developing working with clients to develop patent portfolios, in- and out-licensing, and providing opinions on freedom to operate and patentability. He was a former partner at Alston & Bird, LLP, where was a co-leader of the Intellectual Property Patent Group and the leader of the Biotechnology, Chemical and Pharmaceutical Team. (Hover to Read More)
Murray has extensive experience developing working with clients to develop patent portfolios, in- and out-licensing, and providing opinions on freedom to operate and patentability. He was a former partner at Alston & Bird, LLP, where was a co-leader of the Intellectual Property Patent Group and the leader of the Biotechnology, Chemical and Pharmaceutical Team. On multiple occasions Murray has earned the Raleigh-Durham Area Lawyer of the Year Award for Biotechnology Law and he has been listed in Best Lawyers in America in the areas of Intellectual Property and Biotechnology Law. Murray received his Ph.D. in Genetics from North Carolina State University and his J.D. from The George Washington University Law School.
Luke Steere, Ph.D.
A native of Michigan, Luke received his B.S. from the University of Michigan-Ann Arbor and his PhD from Michigan State University. His graduate research focused on plant-microbe interactions in the rhizosphere, soil microbe population dynamics as they relate to soil-borne plant diseases, and the implementation of next-generation sequencing and spatial/temporal geographical information into integrated pest management. (Hover to Read More)
A native of Michigan, Luke received his B.S. from the University of Michigan-Ann Arbor and his Ph.D. from Michigan State University. His graduate research focused on plant-microbe interactions in the rhizosphere, soil microbe population dynamics as they relate to soil-borne plant diseases, and the implementation of next-generation sequencing and spatial/temporal geographical information into integrated pest management. His post-doctoral research on fungicide resistance management and applied field biology for new product development eventually led to a career in crop protection chemistry discovery and development. At 5Metis, Luke leads the crop protection R&D team located in Research Triangle Park, NC. Outside of work, Luke enjoys golf and fly fishing.
Steve Tuttle, B.S.
Steve is the Chief Operating Officer (COO) and member of the board of directors of 5Metis since June 2024. Currently he also serves as President and CEO of AgriMetis LLC, following years of global agriculture business experience and expertise. In addition, he has been a member of the board of directors of JRJ company (Gowan) since 2018. (Hover to Read More)
Steve is the Chief Operating Officer (COO) and member of the Board of Directors of 5Metis since June 2024. Currently he also serves as President and CEO of AgriMetis LLC, following years of global agriculture business experience and expertise. In addition, he has been a member of the board of directors of JRJ company (Gowan) since 2018. Steven has more than 35 years of global agricultural business experience and expertise, including a demonstrated history of working in the biotechnology, agriculture and renewable energy industries. Steven is skilled in business strategy, development and organizational planning. His experiences include building, running, developing and leading global businesses. Specifically, within the Agricultural Segment he has held several sales, marketing and commercial management roles. One of Steven’s responsibilities has been as global business director for the insecticides and fungicide portfolios within Dow AgroSciences. In addition, he has had responsibility as global business director for the Bioscience platform, Ventures & Business development and Alternative Energy Business (AEB) within The Dow Chemical Company. Steven served as President and Chief Executive Officer of Dow Kokam LLC. He has travelled globally since 1994 and lived for 6 years in Tokyo Japan. He earned a bachelor's degree in Agricultural Engineering from The Ohio State University.
Steven Williams, M.S.
Steven (Stevie) received his B.S. in chemistry from Winston Salem State University, then received his M.S. in chemistry from University of North Carolina at Wilmington with a second concentration on clinical research. He started working as a QC chemist at Vertellus, Inc., and he became a lead QC chemist in one year, while focusing on developing and growing as a chemist. (Hover to Read More)
Steven (Stevie) received his B.S. in chemistry from Winston Salem State University. He then received his M.S. in chemistry from University of North Carolina at Wilmington with a second concentration on clinical research. He started working as a QC chemist at Vertellus, Inc., where he became a lead QC chemist in one year, while focusing on developing and growing as a chemist. Stevie then proceeded to work as a QC chemist at Alberdingk Boley, Inc. Stevie joined the 5Metis team in April 2023 as a research associate chemist, working with the company R&D team. Outside of work, he can be found hanging out with his friends, working out, and watching sports.
Xunhai Zheng, Ph.D.
Dr. Xunhai Zheng received his M.S. degree in the field of natural product chemistry from the China Pharmaceutical University, and then earned his Ph.D. degree from the Shanghai Institute of Organic Chemistry, Chinese Academy Science. (Hover to Read More)
Dr. Xunhai Zheng received his M.S. degrees in the field of natural product chemistry from the China Pharmaceutical University, and then earned his Ph. D. degrees from the Shanghai Institute of Organic Chemistry, Chinese Academy Science. Xunhai joined the National Institute of Environmental Health Sciences (NIEHS) as a postdoc and then as a research fellow in nuclear magnetic resonance group, conducting research on HIV reverse transcriptase conformational changes. Since 2015, he joined Bayer Cropscience in trait discovery as a protein biochemist, and then BASF in microbe discovery as a scientist III, focusing on novel functional gene identification, expression, characterization, also developing new analytical assays and approaches to support the pipeline discovery. As a diligent and innovative senior scientist and protein biochemist, Xunhai offers more than 10 years’ experience in R&D with a solid background in protein biochemistry, organic chemistry, analytic chemistry and biophysics. ​
At 5Metis, Xunhai works as a Senior Analytical Chemist in the crop protection R&D team. He currently has 2 U.S. Patents, and 14 peer reviewed publications (10 first-authors). Outside of work, his hobbies include playing ping-pong, fishing and gardening.
5Metis Scientific Advisory Board (SAB)
Stephen Benkovic, Ph.D.
Dr. Stephen (Steve) J. Benkovic is an Evan Pugh University Professor and Eberly Chair in Chemistry at The Pennsylvania State University. (Hover to Read More)
Dr. Stephen J. Benkovic is an Evan Pugh University Professor and Eberly Chair in Chemistry at The Pennsylvania State University. His research has focused on the assembly and kinetic characteristics of the protein machinery that is responsible for DNA replication; the importance of dynamic coupling of proximal and distal residues in the catalytic cycle of dihydrofolate reductase; the intracellular observation of de novo purine biosynthesis, the collaborative development of novel sound based technologies for studying cellular communication, and development of boron therapeutics. He has been recognized by awards including the Benjamin Franklin Medal in Life Science, the National Medal of Science, and the National Academy of Science Award in Chemical Sciences. He is also a member of the National Academy of Science, the American Academy of Arts and Sciences, the National Academy of Medicine, and the American Philosophical Society.
Philip Goelet, Ph.D.
Philip has extensive experience as a scientist, entrepreneur and investor. After completing a Ph.D. on sequencing Tobacco Mosaic Virus at the Laboratory of Molecular Biology in Cambridge, UK and a postdoctoral fellowship on learning and memory at Columbia University, NY, he turned his attention to biotechnology. (Hover to Read More)
Philip has extensive experience as a scientist, entrepreneur and investor. After completing a Ph.D. on sequencing Tobacco Mosaic Virus at the Laboratory of Molecular Biology in Cambridge, UK and a postdoctoral fellowship on learning and memory at Columbia University, NY, he turned his attention to biotechnology. Since 1990 he has co-founded and invested in a number of biotechnology companies including Molecular Tool, Inc. (acquired by Orchid Biosciences), RiboTargets, Plc. (merged with Vernalis), Population Genetic Technologies, Arginetix (acquired by AstraZeneca), ZuvaChem and AgriMetis. In parallel he co-founded Acidophil LLC, an innovation partnership, with Nobel Laureate Sydney Brenner, and Red Abbey Venture Partners, a health care private equity fund, with Frank Bonsal and Matt Zuga.
Peter Hertl, Ph.D.
Peter is a product safety and regulatory expert with 30 years professional experience in the registration of chemicals and genetically modified organisms. Peter holds a Ph.D. in Chemistry and completed executive leadership coursesat Harvard Business school and IMD Lausanne. (Hover to Read More)
Peter is a product safety and regulatory expert with 30 years professional experience in the registration of chemicals and genetically modified organisms. Peter holds a Ph.D. in Chemistry and completed executive leadership coursesat Harvard Business school and IMD Lausanne. In 1988, after completing his academic training (Ph.D. in physical organic chemistry awarded by the University of Tübingen, he joined the Agrochemical industry. In his first role he and his team focused on human and environmental exposure assessment to agrochemicals. Peter has specific technical expertise in human and environmental exposure and effects, data generation and risk assessment, including mechanistic, probabilistic, stochastic models and methods as well as geospatial analyses. Peter has held numerous management and senior management positions with Syngenta, Novartis and Sandoz, with department sizes up to 900 professionals. As a senior manager he was accountable for:
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The co-creation and implementation of a unique product safety testing and data acquisition strategy with key outcomes in cost and time to market reduction resulting in a significant positive impact on product portfolio value.
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Key contributions to re-engineering and implementing a product invention strategy that ensured the optimum design and selection of molecules for commercial development, resulting in an industry leading innovation pipeline.
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Development of an end-to-end business model for the Safety and Regulatory function in close cross functional stakeholder collaboration including the design and establishment associated processes and governance.